Save 20% on Joint Health products – Jan. 23 – Feb. 3

SAMe 200 mg

SAMe 200 mg

  • Enteric coated
  • Enhanced absorption, bioavailability
  • Enhanced stability
  • Exclusively at Costco
NPN: 80004422

Tested for Allergens






No Artificial Colours or Sweeteners


Planet Friendly


Made with Natural Ingredients


High Quality Ingredients


Gluten Free

SAMe enhanced

Feel Better with SAMe

Supports healthy mood balance

Clinical research shows that SAMe (S-Adenosyl-Methionine) elevates mood and has a positive effect on behaviour. SAMe is a natural compound made by the body that plays a pivotal role in metabolism and contributes to the health of virtually every tissue in the body. As we age, our SAMe production declines, which makes supplementation a great option to maintain the body’s levels. SAMe is also used to address osteoarthritis symptoms and works with folic acid and vitamin B12 to promote good mental health.

Enhanced absorption and bioavailability

Our SAMe is enteric coated, which not only makes it easier to swallow, but also enables the tablet to bypass the stomach completely and go straight to the intestine where it is digested and absorbed. This process allows for maximum absorption and bioavailability as well as enhanced stability.

Label Information

Recommended Purpose

  • Supports healthy mood balance and liver function.
  • Relieves osteoarthritic pain.

SAMe is an abbreviation for S-Adenosyl-Methionine, a natural chemical compound made in the body. SAMe plays a pivotal role in metabolism. However, like with many natural substances our bodies make, SAMe production can decline as we age. SAMe is by far the most important methyl-donor in methylation metabolism, contributing to the health status of virtually every tissue in the body. If SAMe levels decline, so does the vigorous methylation process that contributes to good health. SAMe supplementation has been found to improve a range of health problems and it may be useful in many conditions, including osteoarthritis, and promotes liver health.

Clinical research shows that SAMe elevates mood and has a positive effect on behaviour. It’s also used to address osteoarthritis symptoms and works with folic acid and B12 to promote good mental health. SAMe from Webber Naturals is enteric coated for ease of swallowing, maximum bioavailability, and enhanced stability.

Each tablet contains:
S-Adenosyl-L-Methionine (SAMe) 200 mg

Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, talc, triethyl citrate, silica, titanium dioxide, yellow iron oxide), glyceryl behenate, vegetable grade magnesium stearate (lubricant), silica, sodium starch glycolate.

Recommended dosage (adults): SAMe should always be taken on an empty stomach.
Initial dosage for healthy mood/liver function: 1–4 tablets 2 times daily for 2 weeks.
For osteoarthritis: 1–3 tablets 2 times daily for 2 weeks.
Maintenance dosage: Reduce dose to 1 tablet daily after 2 weeks or as directed by a physician.
Do not exceed a total of 8 tablets per day. Effects should be seen within 2 weeks of starting supplementation.

Free of artificial colours, preservatives or sweeteners; no dairy, sugar, wheat, gluten, soy, egg, fish, shellfish, animal products, salt, tree nuts or GMOs. Suitable for vegetarians/vegans.

Do not take at night since the product may cause anxiety, restlessness and insomnia. If taking antidepressants, hepatotoxic drugs or monoamine oxidase (MAO) inhibitors, consult a physician prior to taking SAMe in place of or in addition to those medications. Not recommended for use in children. Do not use if pregnant or if you have bipolar disorder (manic-depressive illness) unless by approval and under supervision of a physician. Do not use if breastfeeding. Possible side effects are: mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea and flatulence), anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur, they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. Keep out of reach of children.

You May Also Like

Similar products chosen by our team of health care experts